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Type: Artigo de periódico
Title: Tc-99m Sestamibi Thyroid Imaging in Patients on Chronic Amiodarone Treatment A Comparison With Tc-99m Pertechnetate Imaging
Author: Oki, GCR
Zantut-Wittmann, DE
Santos, AD
Guariento, MH
Tambascia, MA
de Almeida, EA
Amorim, BJ
Lima, MCL
Etchebehere, ECSC
Camargo, EE
Ramos, CD
Abstract: Purpose of the Report: To compare thyroid imaging using Tc-99m sestamibi with the standard Tc-99m pertechnetate scintigraphy in patients on chronic use of amiodarone. Materials and Methods: A total of 23 patients on oral amiodarone for at least 4 months had thyroid scintigraphy and uptake measurement using Tc-99m pertechnetate and Tc-99m sestamibi. Thyroid function was evaluated by measuring serum concentrations of thyrotropin, free thyroxine, and free triiodothyronine, and antithyroglobulin and antithyroperoxidase antibodies. Results: Ten of the 23 patients were euthyroid, 9 hypothyroid, and 4 hyperthyroid, with normal, increased, and decreased serum thyrotropin, respectively. All euthyroid patients had markedly decreased thyroid Tc-99m pertechnetate uptake and normal or slightly increased Tc-99m sestamibi uptake, except for one patient who had increased uptake of both radiotracers. One of the 4 hyperthyroid patients had Graves' disease and markedly increased thyroid uptake of both tracers. The other 3 hyperthyroid patients had normal or decreased Tc-99m pertechnetate uptake and increased Tc-99m sestamibi uptake. Differently than expected, all 9 hypothyroid patients had normal or increased uptake of both radiopharmaceuticals. Conclusions: This study suggests that Tc-99m sestamibi may be an alternative tracer for thyroid scintigraphy and uptake measurement of patients on chronic use of amiodarone. Tc-99m sestamibi seems to be better than Tc-99m pertechnetate for the scintigraphic evaluation of the thyroid of euthyroid and hyperthyroid patients.
Subject: thyroid scintigraphy
Tc-99m sestamibi
Tc-99m pertechnetate
thyroid uptake
Country: EUA
Editor: Lippincott Williams & Wilkins
Citation: Clinical Nuclear Medicine. Lippincott Williams & Wilkins, v. 35, n. 4, n. 223, n. 227, 2010.
Rights: fechado
Identifier DOI: 10.1097/RLU.0b013e3181d18e8e
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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