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Type: Artigo de periódico
Title: Testicular Histomorphometry and Ultrastructure of Rats Treated with Cadmium and Ginkgo biloba
Author: Predes, FD
Monteiro, JC
Matta, SLP
Garcia, MC
Dolder, H
Abstract: The aim of this study is to investigate the association of a single low dose of Cd and daily doses of Ginkgo biloba extract (GbE) on the testis and accessory glands of rats. The animals were treated with a single dose of 3 mu mol/kg body weight of cadmium chloride (CdCl(2)) and/or 100 mg/kg body weight of GbE. The plasma testosterone levels; corporal, testicular, and accessory glands weight; gonadosomatic index, volumetric proportion; and absolute volume of testicular components did not change after the treatments. CdCl(2) caused significant reduction in Leydig cells volume and altered Leydig cell morphology, as well as vacuolated Sertoli cells cytoplasm, irregular chromatin condensation of late spermatids, and modified acrosome formation. However, animals that received GbE did not show these alterations. The reversal of Cd-induced alterations by the extract is a strong indication that G. biloba is helpful in diminishing the effect of Cd toxicity.
Subject: Wistar rat
Ginkgo biloba
Morphometry and ultrastructure
Country: EUA
Editor: Humana Press Inc
Citation: Biological Trace Element Research. Humana Press Inc, v. 140, n. 3, n. 330, n. 341, 2011.
Rights: fechado
Identifier DOI: 10.1007/s12011-010-8702-5
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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