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Type: Artigo de periódico
Title: Cell death evaluation in benzo[a]pyrene-transformed human breast epithelial cells after microcell-mediated transfer of chromosomes 11 and 17
Author: Mello, MLS
Barbisan, LF
Lareef, MH
Russo, J
Vidal, BD
Abstract: The incidence of apoptosis and nuclear instability, including the incidence of catastrophic death, were investigated in benzo[a]pyrene (BP)-transformed human breast epithelial cells (BP1-E cell line) after microcell-mediated transfer of chromosomes 11 and 17. Since the introduction of normal chromosomes 11 and 17 into tumorigenic human breast BP1-E cells reverts some of these cells' characteristics (especially those affected by microsatellite instabilities and loss of heterozygosity) those of parental non-transformed MCF-10F cells, it was expected that the cell death rates would also be affected by this treatment. The transfer of the mentioned chromosomes, especially chromosome 17, to tumorigenic BP1-E cells increased the apoptotic ratios and decreased the nuclear instability ratios, thus showing that the microsatellite instability and loss of heterozygosity induced by BP in these chromosomes of MCF-10F cells affect the control of cell death mechanisms. (C) 2003 Elsevier B.V. All rights reserved.
Subject: apoptosis
catastrophic death
human breast epithelial cells
chromosome 11
chromosome 17
Country: Holanda
Editor: Elsevier Science Bv
Citation: Mutation Research-fundamental And Molecular Mechanisms Of Mutagenesis. Elsevier Science Bv, v. 546, n. 41671, n. 39, n. 43, 2004.
Rights: fechado
Identifier DOI: 10.1016/j.mrfmmm.2003.10.005
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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