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Type: Artigo de periódico
Title: Ceftriaxone in the treatment of spontaneous bacterial peritonitis ascitic fluid polymorphonuclear count response and short-term prognosis
Author: Mesquita, MA
Balbino, EPS
Albuquerque, RS
Carmona, CA
Okubo, BT
Lorena, SLS
Montes, CG
Soares, EC
Abstract: Background/Aims: In this study, ascitic fluid polymorphonuclear (PMN) response, short-term prognosis, and factors related to hospital mortality were investigated in 62 cases of spontaneous bacterial peritonitis ocurring in cirrhotic patients treated with Ceftriaxone (1 g every 12 hours). Methodology: The diagnostic criteria for (SBP) were ascitic fluid PMN count <250 cells/mm(3) and no evidence of secondary peritonitis. Analysis of ascitic fluid samples were obtained on admission, and on the 4th and 10th days of antibiotic therapy. Results: The etiology of cirrhosis was alcohol in 63% of the cases, and 79.5% of patients belonged to Child-Pugh Class C. Ascitic fluid analysis showed positive cultures in 47% of the cases, and a marked decrease in PMN count during treatment (admission: 7762 +/- 2837; 4th day: 388 +/- 91; 10th day: 173 +/- 59 cells/mm(3)). Ascitic PMN was <250 cells/mm3 within 4 days of treatment in 33% of the cases. The hospital mortality rate was 24%, and was related to gastrointestinal hemorrhage, hepatic encephalopathy, renal failure and 4th day ascitic fluid PMN count. Conclusion: Ceftriaxone is a safe and effective option for the treatment of SBP.
Subject: ceftriaxone
spontaneous bacterial peritonitis
Country: Grécia
Editor: H G E Update Medical Publ Ltd.
Citation: Hepato-gastroenterology. H G E Update Medical Publ Ltd., v. 44, n. 17, n. 1276, n. 1280, 1997.
Rights: aberto
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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