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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCarotid and uterine vascular resistance in short-term hormone replacement therapy postmenopausal userspt_BR
dc.contributor.authorLazar, Fpt_BR
dc.contributor.authorCosta-Paiva, Lpt_BR
dc.contributor.authorPinto-Neto, AMpt_BR
dc.contributor.authorMartinez, EZpt_BR
unicamp.author.emailflj@uol.com.brpt_BR
unicamp.authorUniv Estadual Campinas, Sch Med Sci, Dept Obstet & Gynecol, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectHRTpt_BR
dc.subjectestrogenpt_BR
dc.subjectpulsatility indexpt_BR
dc.subjectmenopausept_BR
dc.subjectcolor dopplerpt_BR
dc.subjectcarotid arterypt_BR
dc.subjectuterine arterypt_BR
dc.subjectcardiovascular protectionpt_BR
dc.subject.wosEstrogen Plus Progestinpt_BR
dc.subject.wosCoronary-heart-diseasept_BR
dc.subject.wosMiddle Cerebral-arteriespt_BR
dc.subject.wosBlood-flowpt_BR
dc.subject.wosPulsatility Indexpt_BR
dc.subject.wosCardiovascular-diseasept_BR
dc.subject.wosTransdermal Estradiolpt_BR
dc.subject.wosRisk-factorspt_BR
dc.subject.wosWomenpt_BR
dc.subject.wosMenopausept_BR
dc.description.abstractObjective: To compare the short-term effects of oral hormone replacement therapy (HRT) and placebo on carotid and uterine vascular impedance. Methods: 80 postmenopausal women selected from the outpatient clinic of the Hospital Leonor Mendes de Barros in S (a) over baro Paulo, Brazil, were randomized to oral HRT (estradiol 2 mg/norethisterone acetate I mg-Kliogest(r)) or placebo. Carotid and uterine arteries pulsatility indices (PIs) were assessed by color Doppler at baseline, after 4 and 12 weeks of treatment. Seventy-six women completed the trial, 38 in each group. Results: The carotid PI did not decrease significantly in either group. In the uterine arteries, the drop in PI was steeper and greater for HRT women. Drops occurred despite the supposed counteracting effect of norethisterone acetate. In placebo group, there was no significant difference between 4 and 12 weeks of treatment compared with the baseline. The results did not change when analyzed in a real treatment approach. Conclusion: Oral continuous HRT are effective at 12 weeks in reducing impedance to flow in uterine, but not in carotid circulation. These results suggest that the effects of HRT vary by vascular site, and do not have a detectable short-term vascular effect in the carotid area. (C) 2003 Elsevier Ireland Ltd. All rights reserved.pt
dc.relation.ispartofMaturitaspt_BR
dc.relation.ispartofabbreviationMaturitaspt_BR
dc.publisher.cityClarept_BR
dc.publisher.countryIrlandapt_BR
dc.publisherElsevier Sci Ireland Ltdpt_BR
dc.date.issued2004pt_BR
dc.date.monthofcirculationAUG 20pt_BR
dc.identifier.citationMaturitas. Elsevier Sci Ireland Ltd, v. 48, n. 4, n. 472, n. 478, 2004.pt_BR
dc.language.isoenpt_BR
dc.description.volume48pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage472pt_BR
dc.description.lastpage478pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0378-5122pt_BR
dc.identifier.wosidWOS:000223446200017pt_BR
dc.identifier.doi10.1016/j.maturitas.2003.11.003pt_BR
dc.date.available2014-11-14T15:40:37Z
dc.date.available2015-11-26T16:07:18Z-
dc.date.accessioned2014-11-14T15:40:37Z
dc.date.accessioned2015-11-26T16:07:18Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:07:18Z (GMT). No. of bitstreams: 2 WOS000223446200017.pdf: 74730 bytes, checksum: 6d8ba5f43af5fb088b25671108dd8599 (MD5) WOS000223446200017.pdf.txt: 27421 bytes, checksum: 93902f2f88df456ac723cafda578f947 (MD5) Previous issue date: 2004en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78465pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/78465
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78465-
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