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Type: Artigo de periódico
Title: Calcium-binding proteins in skeletal muscles of the mdx mice: potential role in the pathogenesis of Duchenne muscular dystrophy
Author: Pertille, A
de Carvalho, CLT
Matsumura, CY
Neto, HS
Marques, MJ
Abstract: P>Duchenne muscular dystrophy is one of the most common hereditary diseases. Abnormal ion handling renders dystrophic muscle fibers more susceptible to necrosis and a rise in intracellular calcium is an important initiating event in dystrophic muscle pathogenesis. In the mdx mice, muscles are affected with different intensities and some muscles are spared. We investigated the levels of the calcium-binding proteins calsequestrin and calmodulin in the non-spared axial (sternomastoid and diaphragm), limb (tibialis anterior and soleus), cardiac and in the spared extraocular muscles (EOM) of control and mdx mice. Immunoblotting analysis showed a significant increase of the proteins in the spared mdx EOM and a significant decrease in the most affected diaphragm. Both proteins were comparable to the cardiac muscle controls. In limb and sternomastoid muscles, calmodulin and calsequestrin were affected differently. These results suggest that differential levels of the calcium-handling proteins may be involved in the pathogenesis of myonecrosis in mdx muscles. Understanding the signaling mechanisms involving Ca2+-calmodulin activation and calsequestrin expression may be a valuable way to develop new therapeutic approaches to the dystrophinopaties.
Subject: calmodulin
cardiac muscle
Duchenne muscular dystrophy
extraocular muscles
Country: EUA
Editor: Wiley-blackwell Publishing, Inc
Citation: International Journal Of Experimental Pathology. Wiley-blackwell Publishing, Inc, v. 91, n. 1, n. 63, n. 71, 2010.
Rights: fechado
Identifier DOI: 10.1111/j.1365-2613.2009.00688.x
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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