Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/78283
Type: Artigo de periódico
Title: Caffeine reduces cadmium accumulation in the organism and enhances the levels of antioxidant protein expression in the epididymis
Author: Lacorte, LM
Seiva, FRF
Rinaldi, JC
Delella, FK
Moroz, A
Sarobo, C
Godinho, AF
Favaro, WJ
Fernandes, AAH
Felisbino, SL
Abstract: The aim of this study was to investigate the effects of caffeine (20 mg/L) intake on cadmium (15 mg/L) accumulation in the rat blood, testes, epididymis and prostate as well as cadmium-induced changes to the antioxidant defense system of the epididymis. Caffeine reduced the cadmium concentration in all tissues analyzed. Meanwhile, cadmium reduced catalase activity and increased superoxide dismutase (SOD) activity in the epididymis. Caffeine increased SOD activity, catalase and glutathione tissue expression and sustains the cadmium's effect on catalase and GSP-Px activity. No differences in the expression of metallothionein and lipid peroxidation were observed among the different treatments in the epididymis. In conclusion, low doses of cadmium alter the antioxidant enzymatic profile of the epididymis, but not induced oxidative lipid damage. Caffeine intake reduces overall cadmium accumulation in the organism and enhances the levels of antioxidant protein expression in the epididymis, thus exerting a protective effect against this metal. (C) 2012 Elsevier Inc. All rights reserved.
Subject: Cadmium
Caffeine
Accumulation
Oxidative stress
Male reproductive tract
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.reprotox.2012.10.009
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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