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Type: Artigo de periódico
Title: Brain hypoperfusion in adolescents dependent of multiple drugs
Author: Etchebehere, ECSD
Oliveira, FM
Amorim, BJ
Serrat, SM
Camargo, EE
Abstract: Brain SPECT imaging (BSI) with statistical parametric mapping (SPM) offers a clear and accurate vision of perfusion changes. Objective: To study brain perfusion abnormalities in adolescents' dependent of multiple drugs. Method: Sixteen male patients (15.1 +/- 2.1 years) were submitted to (99m)Tc-HMPAO BSI with SPM. Results: Cortical hypoperfusion occurred in 7/16 patients (44%). There was a significant inverse correlation between the number of hypoperfused regions and the patient's age (p= -0.6737; p=0.004) and with the age when the drug dependence began (p= -0.5616; p=0.023). There was also a tendency towards an inverse correlation between regions of hypoperfusion and the duration of the drug dependence. Conclusion: BSI with SPM can help detect hypoperfusion in adolescents dependent on multiple drugs. The younger the patients, the more regions of hypoperfusion are noted. Probably, the neuronal plasticity has an important role in this phenomenon because the highest neural activity occurs in childhood.
Subject: computed tomography
substance-related disorders
drug abuse
drug addiction
substance abuse
substance dependence drug abuse
Country: Brasil
Editor: Assoc Arquivos Neuro- Psiquiatria
Citation: Arquivos De Neuro-psiquiatria. Assoc Arquivos Neuro- Psiquiatria, v. 68, n. 2, n. 161, n. 167, 2010.
Rights: aberto
Identifier DOI: 10.1590/S0004-282X2010000200002
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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