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Type: Artigo de periódico
Title: The mouse pubic symphysis as a remodeling system: morphometrical analysis of proliferation and cell death during pregnancy, partus and postpartum
Author: Veridiano, AM
Garcia, EA
Pinheiro, MC
Nishimori, FY
Toledo, OMS
Joazeiro, PP
Abstract: Marked changes in mice pubic symphysis occur by the end of pregnancy. Tissue remodeling involves a dynamic balance between cell proliferation and programmed cell death as well as changes in the extracellular matrix components. Therefore, it is important to consider both of these cellular behaviors when investigating the mechanism that regulates interpubic tissue remodeling, growth during late pregnancy and partus ensuring involution during the postpartum period. Proliferating and programmed death cells were identified by immunohistochemistry (proliferating cell nuclear antigen and TUNEL detection, respectively) and the rates at which these processes occurred were determined by morphometric analysis. The results demonstrated that cellular proliferation was intense during the period of ligament formation, from D15 to D18, thereafter abruptly declining on D19. From parturition (D19) onwards, an ever-increasing decline in the cellular proliferation levels could be observed. The quantitative analyses of cellular death showed opposite results when compared to cellular proliferation. During early pregnancy the cycle of cellular renovation was clearly proliferative and during late mouse pregnancy the cycle was directed by programmed cellular death. Although the high levels of cellular death during postpartum involution could be shown by the TUNEL-positive cells, we were unable to observed picnotic nucleus at the light microscopy.
Subject: pubic symphysis
cell proliferation
cellular death
tissue remodeling
mouse (Swiss, female)
Country: EUA
Editor: Springer
Citation: Cell And Tissue Research. Springer, v. 330, n. 1, n. 161, n. 167, 2007.
Rights: fechado
Identifier DOI: 10.1007/s00441-007-0463-x
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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