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Type: Artigo de periódico
Title: The CALM and CALM/AF10 interactor CATS is a marker for proliferation
Author: Archangelo, LF
Greif, PA
Holzel, M
Harasim, T
Kremmer, E
Przemeck, GKH
Eick, D
Deshpande, AJ
Buske, C
de Angelis, MH
Saad, STO
Bohlander, SK
Abstract: The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Subject: CALM/AF10
Country: Inglaterra
Editor: Elsevier Sci Ltd
Citation: Molecular Oncology. Elsevier Sci Ltd, v. 2, n. 4, n. 356, n. 367, 2008.
Rights: fechado
Identifier DOI: 10.1016/j.molonc.2008.08.001
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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