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|Type:||Artigo de periódico|
|Title:||Bone marrow progenitor cells from chemically exposed workers display an intrinsic ability for autonomous proliferation|
de Melo, A
|Abstract:||In this study, the autonomous proliferation of bone marrow progenitor cells (CFU-C), a pathological phenomenon observed in many hematological abnormalities, was investigated in 31 individuals who had been diagnosed as having neutropenia. Of these subjects, 18 had been chronically exposed (range of exposure 5-30 years) to a variety of petroleum distillates. We observed that the group of exposed individuals presented higher numbers of autonomous CFU-C when compared with those unexposed subjects. In addition, follow-up data demonstrated that 20% of the exposed population (4 of the 18) developed malignant hematological diseases. The autonomous CFU-C obtained from all individuals studied was composed predominantly of macrophages. This suggests an involvement of these cells in the development of hematological abnormalities, probably as a result of increased production of chemical myelotoxic metabolites.|
|Editor:||Taylor & Francis Inc|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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