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Type: Artigo de periódico
Title: Bone marrow progenitor cells from chemically exposed workers display an intrinsic ability for autonomous proliferation
Author: Valadares, MC
Bincoletto, C
Oliveira, SC
de Melo, A
Saad, STO
Queiroz, MLS
Abstract: In this study, the autonomous proliferation of bone marrow progenitor cells (CFU-C), a pathological phenomenon observed in many hematological abnormalities, was investigated in 31 individuals who had been diagnosed as having neutropenia. Of these subjects, 18 had been chronically exposed (range of exposure 5-30 years) to a variety of petroleum distillates. We observed that the group of exposed individuals presented higher numbers of autonomous CFU-C when compared with those unexposed subjects. In addition, follow-up data demonstrated that 20% of the exposed population (4 of the 18) developed malignant hematological diseases. The autonomous CFU-C obtained from all individuals studied was composed predominantly of macrophages. This suggests an involvement of these cells in the development of hematological abnormalities, probably as a result of increased production of chemical myelotoxic metabolites.
Subject: occupational exposure
petroleum distillates
haematological abnormalities
autonomous CFU-C
Country: EUA
Editor: Taylor & Francis Inc
Citation: Immunopharmacology And Immunotoxicology. Taylor & Francis Inc, v. 27, n. 1, n. 137, n. 145, 2005.
Rights: fechado
Identifier DOI: 10.1081/IPH-200051761
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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