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Type: Artigo de periódico
Title: Bone filling around titanium implants may benefit from smoking cessation: A histologic study in rats
Author: Cesar-Neto, JB
Benatti, BB
Sallum, EA
Sallum, AW
Nociti, FH
Abstract: Background: Although a harmful effect of smoking on titanium implants has been documented, only a few studies have investigated the benefits of smoking cessation. Thus, this study histologically investigated whether smoking cessation influences bone healing around titanium implants and comparatively evaluated temporary versus complete cessation protocols. Methods: Sixty-six male Wistar rats were randomly assigned to one of four groups: control (N = 16); CSI, intermittent cigarette smoke inhalation (CSI) throughout the entire 150-day experiment (N = 17); P-CSI, CSI 83 days prior to implant placement (N = 17); or R-CSI, CSI for 83 days, cessation 7 days before and 21 weeks after implant placement, and return to CSI for 39 days (N = 16). The animals were sacrificed and the degree of bone-to-implant contact (BIC) and the bone area (BA) within the limits of the implant threads obtained for cortical (zone A) and cancellous bone (zone B). Results: Intergroup analysis (Kruskal-Wallis test, alpha = 0.05) demonstrated a significant effect of CSI on BA (P < 0.05) and that temporary or complete CSI cessation protocols resulted in values similar to those of the control group (P > 0.05) 88.91% +/- 4.29%; 80.66% +/- 6.55%; 84.27% +/- 6.96%; 85.71% +/- 4.7% in zone A, and 51.28% +/- 6.49%; 38.69% +/- 10.78%; 48.87% +/- 8.47%; 49.47% +/- 8.04%; in zone B for groups CTRL, CSI, P-CSI, and R-CSI, respectively. Conclusion: Within the limits of the present investigation, temporary and complete CSI cessation reversed the effect of smoke exposure on bone healing around titanium implants in both cortical and cancellous bone.
Subject: animal studies
bone and bones
dental implants
smoking/adverse effects
smoking cessation
wound healing
Country: EUA
Editor: Amer Acad Periodontology
Citation: Journal Of Periodontology. Amer Acad Periodontology, v. 76, n. 9, n. 1476, n. 1481, 2005.
Rights: fechado
Identifier DOI: 10.1902/jop.2005.76.9.1476
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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