Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/78041
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAppetite-regulating hormones from the upper gut: disrupted control of xenin and ghrelin in night workerspt_BR
dc.contributor.authorSchiavo-Cardozo, Dpt_BR
dc.contributor.authorLima, MMOpt_BR
dc.contributor.authorPareja, JCpt_BR
dc.contributor.authorGeloneze, Bpt_BR
unicamp.author.emaildani_sc@hotmail.compt_BR
unicamp.authorSchiavo-Cardozo, Daniela Lima, Marcelo M. O. Pareja, Jose Carlos Geloneze, Bruno Univ Estadual Campinas, UNICAMP, Lab Invest Metab & Diabet LIMED, Gastroctr, Campinas, Brazilpt_BR
dc.subject.wosShift Workpt_BR
dc.subject.wosGlucose-tolerancept_BR
dc.subject.wosInsulin-secretionpt_BR
dc.subject.wosLeptin Levelspt_BR
dc.subject.wosSleeppt_BR
dc.subject.wosMenpt_BR
dc.subject.wosReleasept_BR
dc.subject.wosQualitypt_BR
dc.subject.wosHumanspt_BR
dc.subject.wosHungerpt_BR
dc.description.abstractObjectiveShift work is associated with circadian rhythm disorder, impaired sleep and behavioural changes, including eating habits, predisposing to obesity and metabolic dysfunctions. It involves a neuro-hormonal dysregulation of appetite towards positive energy balance, including increased ghrelin and decreased leptin, but little is known about other hormones, such as xenin, derived from the upper gut (like ghrelin), and lower gut hormones. Our objective was to compare night workers with day workers in relation to appetite-regulating hormones and other metabolic parameters. DesignCross-sectional, observational study. ParticipantsTwenty-four overweight women, divided into night shift workers (n=12) and day shift workers (n=12). MeasurementsBMI, waist circumference, fat mass percentage; diet composition; Pittsburgh Sleep Quality Index; lipids; adipokines; meal tolerance test curves of glucose, insulin, ghrelin, PYY3-36, oxyntomodulin, xenin, GLP-1; insulin sensitivity (Stumvoll index). ResultsNight workers, as compared with day workers, had greater body fat mass percentage and tendency to greater waist circumference despite similar BMI; greater energy intake; impaired sleep; lower insulin sensitivity; increased triglycerides and tendency to increased C-reactive protein; similar levels of leptin and other adipokines. Night workers had a blunted post-meal suppression of ghrelin (AUCi(0-60min) 19<bold>41399</bold> vs -141<bold>9</bold>+/- 9<bold>0</bold>ng/ml<bold>60</bold>min, P<0<bold>01</bold>); blunted rise of xenin (AUC(0-180min) 8690<bold>9</bold>+/- 2988<bold>2</bold> vs 28504<bold>4</bold>+/- 20308<bold>3</bold>pg/ml<bold>180</bold>min, P<0<bold>01</bold>) and similar curves of PYY3-36, oxyntomodulin and GPL-1. ConclusionCompared with day workers within the same BMI range, night workers presented a disrupted control of ghrelin and xenin, associated with behavioural changes in diet and sleep and increased adiposity and related metabolic alterations.pt
dc.relation.ispartofClinical Endocrinologypt_BR
dc.relation.ispartofabbreviationClin. Endocrinol.pt_BR
dc.publisher.cityHobokenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-blackwellpt_BR
dc.date.issued2013pt_BR
dc.date.monthofcirculationDECpt_BR
dc.identifier.citationClinical Endocrinology. Wiley-blackwell, v. 79, n. 6, n. 807, n. 811, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume79pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage807pt_BR
dc.description.lastpage811pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0300-0664pt_BR
dc.identifier.eissn1365-2265pt_BR
dc.identifier.wosidWOS:000326640500009pt_BR
dc.identifier.doi10.1111/cen.12114pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-08-01T18:22:53Z
dc.date.available2015-11-26T17:00:16Z-
dc.date.accessioned2014-08-01T18:22:53Z
dc.date.accessioned2015-11-26T17:00:16Z-
dc.description.provenanceMade available in DSpace on 2014-08-01T18:22:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:00:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78041
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78041-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.