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Type: Artigo de periódico
Title: Apoliprotein E genotype is associated with apoliprotein B plasma levels but not with coronary calcium score in very elderly individuals in primary care setting
Author: Henriques, AD
Tonet-Furioso, AC
Machado-Silva, W
Freitas, WM
Quaglia, LA
Santos, SN
Cordova, C
Sposito, AC
Nobrega, OT
Abstract: Background: Epidemiological surveys indicate the influence of polymorphisms of apolipoprotein (apo) E on plasma lipids and triglyceride-rich lipoprotein levels, with impact on atherosclerotic phenotypes. Aim: We studied the association of classic genotypes of the apoE gene with clinical and biochemical risk factors for atherosclerosis in a segment of the very-old Brazilian individuals, with emphasis on the lipemic profile. Methods: We performed cross-sectional analyses of clinical and laboratory assessments, including cardiac computed tomography, across epsilon 2, epsilon 3 and epsilon 4 carriers of the apoE gene with a convenience sample of 208 participants eligible for prevention against cardiovascular events. Results: When non-epsilon 4 carriers were compared with epsilon 4 carrying subjects, lower levels of ApoB as well as ApoB/ApoA ratios were observed in the former group. Tests between apoE polymorphisms with other clinical/biochemical variables and those with arterial calcification showed no significant differences between groups. Conclusion: The study suggests a possible atherogenic role of the epsilon 4 allele attributable to increased ApoB levels and ApoB/ApoA ratios among very-old subjects in primary care setting. (C) 2014 Elsevier B.V. All rights reserved.
Subject: Apolipoprotein
Lipid metabolism
Primary prevention
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.gene.2014.01.077
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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