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|Type:||Artigo de periódico|
|Title:||Apoliprotein E genotype is associated with apoliprotein B plasma levels but not with coronary calcium score in very elderly individuals in primary care setting|
|Abstract:||Background: Epidemiological surveys indicate the influence of polymorphisms of apolipoprotein (apo) E on plasma lipids and triglyceride-rich lipoprotein levels, with impact on atherosclerotic phenotypes. Aim: We studied the association of classic genotypes of the apoE gene with clinical and biochemical risk factors for atherosclerosis in a segment of the very-old Brazilian individuals, with emphasis on the lipemic profile. Methods: We performed cross-sectional analyses of clinical and laboratory assessments, including cardiac computed tomography, across epsilon 2, epsilon 3 and epsilon 4 carriers of the apoE gene with a convenience sample of 208 participants eligible for prevention against cardiovascular events. Results: When non-epsilon 4 carriers were compared with epsilon 4 carrying subjects, lower levels of ApoB as well as ApoB/ApoA ratios were observed in the former group. Tests between apoE polymorphisms with other clinical/biochemical variables and those with arterial calcification showed no significant differences between groups. Conclusion: The study suggests a possible atherogenic role of the epsilon 4 allele attributable to increased ApoB levels and ApoB/ApoA ratios among very-old subjects in primary care setting. (C) 2014 Elsevier B.V. All rights reserved.|
|Editor:||Elsevier Science Bv|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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