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Type: Artigo de periódico
Title: Apolipoproteins AI, B, and E polymorphisms in severe aortic valve stenosis
Author: Avakian, SD
Annicchino-Bizzacchi, JM
Grinberg, M
Ramires, JAF
Mansur, AP
Abstract: Hypercholesterolemia has been related to aortic valve stenosis (AS). Polymorphisms of apolipoproteins (apo) AI, B, and E are associated with variable levels of plasma lipids, but the association between these polymorphisms and AS is unknown. In a case-control study of groups matched by age, sex, comparable body mass index, hypertension, triglycerides, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol, we analyzed the distribution of apo AI A/G mutation, apo B signal peptide insertion/deletion, apo B XbaI restriction fragment length, and apo E polymorphisms in 62 non-diabetic patients with severe aortic valve stenosis and 62 control subjects. All patients underwent echocardiographic analysis. Univariate analysis showed a higher prevalence of the XbaI X + /X + genotype (p = 0.007) of apo B and the apo E2 allele (p = 0.034) in patients with severe AS. Apo polymorphisms were not associated with lipid levels, left ventricular mass, or the aortic gradient.
Subject: aortic valve stenosis
Country: Dinamarca
Editor: Munksgaard Int Publ Ltd
Citation: Clinical Genetics. Munksgaard Int Publ Ltd, v. 60, n. 5, n. 381, n. 384, 2001.
Rights: fechado
Identifier DOI: 10.1034/j.1399-0004.2001.600511.x
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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