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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleApelin: A Peptide Involved in Cardiovascular Risk in Hemodialysis Patients?pt_BR
dc.contributor.authorLeal, VOpt_BR
dc.contributor.authorLobo, JCpt_BR
dc.contributor.authorStockler-Pinto, MBpt_BR
dc.contributor.authorFarage, NEpt_BR
dc.contributor.authorCalixto, Apt_BR
dc.contributor.authorGeloneze, Bpt_BR
dc.contributor.authorMafra, Dpt_BR
unicamp.authorLeal, Viviane O. Mafra, Denise Univ Fed Fluminense, Programa Posgrad Ciencias Med, Niteroi, RJ, Brazilpt_BR
unicamp.authorLobo, Julie C. Stockler-Pinto, Milena B. Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Ctr Ciencias Saude, Rio de Janeiro, Brazilpt_BR
unicamp.authorFarage, Najla E. Clin RenalCor, Rio De Janeiro, Brazilpt_BR
unicamp.authorCalixto, Antonio Geloneze, Bruno Univ Estadual Campinas UNICAMP, Lab Invest Metab & Diabet, Campinas, SP, Brazilpt_BR
dc.subjectoxidative stresspt_BR
dc.subject.wosEndogenous Ligand Apelinpt_BR
dc.subject.wosStage Renal-diseasept_BR
dc.subject.wosHuman Apj Receptorpt_BR
dc.subject.wosOxidative Stresspt_BR
dc.description.abstractInflammation, oxidative stress, and obesity are important features associated with pathogenesis of cardiovascular disease, a major contributor to the mortality of hemodialysis (HD) patients. Apelin is an adipokine involved in a variety of physiological functions; however, little is known about apelin in chronic kidney disease (CKD). Thus, the purpose of this study was to analyze apelin plasma levels in HD patients and verify whether there is any relationship with inflammation, oxidative markers, and obesity. Twenty-four HD patients [53.6 +/- 14.4 years, 14 men, and body mass index (BMI) of 25.0 +/- 4.2 kg/m(2)] were studied and compared with 15 healthy subjects (51.3 +/- 13.5 years, 7 men, and BMI of 26.3 +/- 3.7 kg/m(2)). Plasma apelin-12 and -36 were measured using the enzyme immunometric assay method. Plasma electronegative low-density lipoprotein [LDL(-)] levels were measured using ELISA method, and tumor necrosis factor-alpha, interleukin-6, leptin, and plasminogen activator inhibitor-1 levels were measured by a multiplex assay kit. C-Reactive protein (CRP) was determined by immunoturbidimetry. Anthropometric data were also evaluated. There was no difference between apelin-36 levels in HD patients (0.82 +/- 0.60 ng/mL) and healthy subjects (0.83 +/- 0.23 ng/mL). In contrast, apelin-12 levels were significantly higher in patients (0.34 +/- 0.15 ng/mL vs. 0.24 +/- 0.13 ng/mL in healthy subjects). TNF-alpha, CRP, and LDL(-) levels were higher in patients; however, there was no correlation among apelin-12 or -36 and inflammatory or oxidative markers. The adiposity parameters were also not associated with apelin-12 or -36. In conclusion, plasma apelin seems to be not associated with cardiovascular risk in HD
dc.relation.ispartofRenal Failurept_BR
dc.relation.ispartofabbreviationRen. Fail.pt_BR
dc.publisherInforma Healthcarept_BR
dc.identifier.citationRenal Failure. Informa Healthcare, v. 34, n. 5, n. 577, n. 581, 2012.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipUnidade de Pesquisa Clinica (UCP)-HUAP-UFFpt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.provenanceMade available in DSpace on 2014-08-01T18:22:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:55:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
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