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Type: Artigo de periódico
Title: Antiviral Activity of Bacillus sp Isolated from the Marine Sponge Petromica citrina against Bovine Viral Diarrhea Virus, a Surrogate Model of the Hepatitis C Virus
Author: Bastos, JCS
Kohn, LK
Fantinatti-Garboggini, F
Padilla, MA
Flores, EF
da Silva, BP
de Menezes, CBA
Arns, CW
Abstract: The Hepatitis C virus causes chronic infections in humans, which can develop to liver cirrhosis and hepatocellular carcinoma. The Bovine viral diarrhea virus is used as a surrogate model for antiviral assays for the HCV. From marine invertebrates and microorganisms isolated from them, extracts were prepared for assessment of their possible antiviral activity. Of the 128 tested, 2 were considered active and 1 was considered promising. The best result was obtained from the extracts produced from the Bacillus sp. isolated from the sponge Petromica citrina. The extracts 555 (500 mu g/ mL, SI> 18) and 584 (150 mu g/ mL, SI 27) showed a percentage of protection of 98% against BVDV, and the extract 616, 90% of protection. All of them showed activity during the viral adsorption. Thus, various substances are active on these studied organisms and may lead to the development of drugs which ensure an alternative therapy for the treatment of hepatitis C.
Subject: hepatitis C virus
antiviral agents
marine microorganisms
Country: Suíça
Editor: Mdpi Ag
Citation: Viruses-basel. Mdpi Ag, v. 5, n. 5, n. 1219, n. 1230, 2013.
Rights: aberto
Identifier DOI: 10.3390/v5051219
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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