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Type: Artigo de periódico
Title: Antiulcerogenic activity of some sesquiterpene lactones isolated from Artemisia annua
Author: Foglio, MA
Dias, PC
Antonio, MA
Possenti, A
Rodrigues, RAF
da Silva, EF
Rehder, VLG
de Carvalho, JE
Abstract: Artemisinin 1, dihydro-epideoxyarteannuin B 2 and deoxyartemisinin 3 were isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L. These compounds were tested on ethanol and indomethacin-induced ulcer models. Compound 1 did not afford cytoprotection under the experimental models tested. Only compounds 2 and 3 decreased the ulcerative lesion index produced by ethanol and indomethacin in rats. These compounds did not demonstrate antiulcerogenic activity when tested on the ethanol-induced ulcer model, with previous administration of indomethacin, suggesting that the antiulcerogenic activity is a consequence of prostaglandin synthesis increase.
Subject: Artemisia annua
antiulcer activity
Country: Alemanha
Editor: Georg Thieme Verlag Kg
Rights: aberto
Identifier DOI: 10.1055/s-2002-32570
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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