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Type: Artigo de periódico
Title: Antiproliferative activity, isolation and identification of active compound from Gaylussacia brasiliensis
Author: Rodrigues, RAF
de Carvalho, JE
Sousa, IMD
Antonio, MA
Pizao, PE
Kohn, LK
do Amaral, MDE
Bittrich, V
Foglio, MA
Abstract: Gaylussacia brasiliensis (Spreng.) Meissn., Ericaceae, is used in folk medicine for treatment of several inflammatory processes and as healing agent. The scope of this work was to evaluate the in vitro antiproliferative activity of crude dichloromethane extract (CHD) and to identify the compound(s) responsible for this activity. CHD was evaluated and showed a concentration dependent inhibition on all cells lines. Therefore CHD was submitted to several classical columns chromatography providing the most active fraction (FC), inhibiting all cells line at 25 mu g/mL. FC was further fractionated affording isolated compound 2 beta, 3 beta-dihydroxy-urs-12-ene-28-oic acid, identified on basis of 2D-NMR experiments and showed concentration-dependent activity and selectivity for kidney and breast cell lines.
Subject: antiproliferative
Gaylussacia brasiliensis
medicinal plants
Country: Brasil
Editor: Soc Brasileira Farmacognosia
Citation: Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Soc Brasileira Farmacognosia, v. 21, n. 4, n. 622, n. 626, 2011.
Rights: aberto
Identifier DOI: 10.1590/S0102-695X2011005000116
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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