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Type: Artigo de periódico
Title: Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines
Author: Savietto, JP
Furlan, CM
Motta, LB
Salatino, MLF
Carvalho, JE
Ruiz, ALTG
Salatino, A
Santos, DYAC
Abstract: Several species of Croton have been described with biological activities, mainly due to diterpenes, alkaloids and/or other secondary metabolites. These activities account for the traditional use of Croton species to treat certain diseases in South America, Asia and Western Africa. The crude methanol extracts obtained from leaves and steam bark of Croton dichrous Mull. Arg., C. erythroxyloides Baill., C. myrianthus Mull. Arg. and C. splendidus Mart. ex Colla were tested for antiproliferative activity against ten human cancer cell lines. Chemical analyses of all extracts were carried out by GC/MS and HPLC/MS/MS. The leaf extract obtained from C. erythroxyloides showed potent activity against PC-3 (prostate) and OVCAR-3 (ovary) cell lines. Lupeol is suggested to be involved in such activity. Tiliroside, an acyl-glycosilated flavonoid ubiquitous in all tested extracts, seems to play an important role in the observed moderate activity of most extracts against the leukemia K562 cell lineage.
Subject: antiproliferative activity
human cell lines
methanol extract
Country: Brasil
Editor: Soc Brasileira Farmacognosia
Citation: Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Soc Brasileira Farmacognosia, v. 23, n. 4, n. 662, n. 667, 2013.
Rights: aberto
Identifier DOI: 10.1590/S0102-695X2013005000058
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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