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Type: Artigo de periódico
Title: Antiproliferative activity of arborescidine alkaloids and derivatives
Author: Santos, LS
Theoduloz, C
Pilli, RA
Rodriguez, J
Abstract: Current issues in cancer research involve searching for novel anticancer compounds that can be used to regulate the cell cycle and lead to more effective treatments of tumors. In this study, it was hypothesized that possessing a cyclic alkaloid similar to harmine, arborescidines can disrupt the proliferative state of cancer cells and block the activity of topoisomerases. The antiproliferative activity of arborescidines A-C and their derivatives was evaluated in vitro against four human tumor cell lines: gastric adenocarcinoma, lung cancer, bladder carcinoma and leukemia. Assuming the mechanism of action by topoisomerase II binding model, the compounds possessing the greatest activity had nonpolar side-chain into hydrophobic binding region on the DNA/topo II complex. (C) 2009 Elsevier Masson SAS. All rights reserved.
Subject: Arborescidine
Cytotoxic activity
Noyori catalyst
Country: França
Editor: Elsevier France-editions Scientifiques Medicales Elsevier
Citation: European Journal Of Medicinal Chemistry. Elsevier France-editions Scientifiques Medicales Elsevier, v. 44, n. 9, n. 3810, n. 3815, 2009.
Rights: fechado
Identifier DOI: 10.1016/j.ejmech.2009.04.005
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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