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Type: Artigo de periódico
Title: Tolerability and safety profile of sildenafil citrate (Viagra((R))) in Latin American patient populations
Author: Coelho, OR
Abstract: Safety data from 546 men with erectile dysfunction (ED) enrolled in three double-blind, placebo-controlled studies conducted in distinct regions of Latin America were pooled and analyzed. The most commonly reported adverse events of all causalities associated with sildenafil treatment were headache (19%), flushing (14%), dyspepsia (6%), and nasal congestion (4%), reflecting the inhibitory effects of sildenafil on cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) in the peripheral vasculature, gastroesophageal sphincter, and nasal mucosa. Visual symptoms were reported in 5.5%, reflecting sildenafil's minor inhibitory effects on cGMP-specific PDE6 in the retina. These adverse events were generally transient and mild, and rarely resulted in discontinuation of sildenafil therapy. Thus, in this representative sample of Latin American men with ED, including those with concomitant stable cardiovascular disease, sildenafil treatment was well tolerated with an incident rate of adverse events similar to reports from other patient populations.
Subject: erectile dysfunction
Country: Inglaterra
Editor: Nature Publishing Group
Citation: International Journal Of Impotence Research. Nature Publishing Group, v. 14, n. S54, n. S59, 2002.
Rights: fechado
Identifier DOI: 10.1038/sj.ijir.3900899
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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