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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleTNF-alpha TRANSIENTLY INDUCES ENDOPLASMIC RETICULUM STRESS AND AN INCOMPLETE UNFOLDED PROTEIN RESPONSE IN THE HYPOTHALAMUSpt_BR
dc.contributor.authorDenis, RGpt_BR
dc.contributor.authorArruda, APpt_BR
dc.contributor.authorRomanatto, Tpt_BR
dc.contributor.authorMilanski, Mpt_BR
dc.contributor.authorCoope, Apt_BR
dc.contributor.authorSolon, Cpt_BR
dc.contributor.authorRazolli, DSpt_BR
dc.contributor.authorVelloso, LApt_BR
unicamp.author.emaillavelloso@fcm.unicamp.brpt_BR
unicamp.authorVelloso, L. A. Univ Estadual Campinas, Dept Clin Med, Lab Cell Signaling, BR-13084970 Campinas, SP, Brazilpt_BR
dc.subjectobesitypt_BR
dc.subjectdiabetespt_BR
dc.subjectfood intakept_BR
dc.subjectleptinpt_BR
dc.subjectinsulinpt_BR
dc.subjectcytokinept_BR
dc.subject.wosDiet-induced Obesitypt_BR
dc.subject.wosEr Stresspt_BR
dc.subject.wosLeptin Resistancept_BR
dc.subject.wosBody-weightpt_BR
dc.subject.wosFood-intakept_BR
dc.subject.wosKappa-bpt_BR
dc.subject.wosActivationpt_BR
dc.subject.wosInsulinpt_BR
dc.subject.wosInflammationpt_BR
dc.subject.wosExpressionpt_BR
dc.description.abstractIn diet-induced obesity, hypothalamic inflammation is triggered as an outcome of prolonged exposure to dietary fats. Toll-like receptor 4 (TLR4) activation plays a central role in this process, inducing endoplasmic reticulum stress and activating inflammatory cytokine gene transcription. Although saturated fatty acids can induce endoplasmic reticulum stress in the hypothalamus, it is unknown whether inflammatory cytokines alone can activate this mechanism. Here, rats were treated with TNF-alpha or lyposaccharide (LPS) and endoplasmic reticulum stress and unfolded protein response were evaluated by immunoblot and polymerase chain reaction (PCR). Activation of TLR4 by LPS was capable of inducing a complete endoplasmic reticulum stress and unfolded protein response through the PERK/eIF2 alpha and IRE1 alpha/XBP1 pathways. Conversely, TNF-a, injected either locally or systemically, was unable to induce a complete program of unfolded protein response, although the activation of endoplasmic reticulum stress was achieved to a certain degree. Thus, in the hypothalamus, the isolated action of TNF-alpha is insufficient to produce the activation of a complete program of unfolded protein response. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved. Key words: obesity, diabetes, food intake, leptin, insulin, cytokine.pt
dc.relation.ispartofNeurosciencept_BR
dc.relation.ispartofabbreviationNeurosciencept_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherPergamon-elsevier Science Ltdpt_BR
dc.date.issued2010pt_BR
dc.date.monthofcirculation40483pt_BR
dc.identifier.citationNeuroscience. Pergamon-elsevier Science Ltd, v. 170, n. 4, n. 1035, n. 1044, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume170pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage1035pt_BR
dc.description.lastpage1044pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0306-4522pt_BR
dc.identifier.wosidWOS:000283524500007pt_BR
dc.identifier.doi10.1016/j.neuroscience.2010.08.013pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2014-11-15T10:30:10Z
dc.date.available2015-11-26T17:19:26Z-
dc.date.accessioned2014-11-15T10:30:10Z
dc.date.accessioned2015-11-26T17:19:26Z-
dc.description.provenanceMade available in DSpace on 2014-11-15T10:30:10Z (GMT). No. of bitstreams: 1 WOS000283524500007.pdf: 2231081 bytes, checksum: 5016aead0b1fc249ca664c615da33ab0 (MD5) Previous issue date: 2010en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:19:26Z (GMT). No. of bitstreams: 2 WOS000283524500007.pdf: 2231081 bytes, checksum: 5016aead0b1fc249ca664c615da33ab0 (MD5) WOS000283524500007.pdf.txt: 38842 bytes, checksum: e1ae4820769061fa4ae99ad317512730 (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77971pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/77971
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77971-
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