Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/77960
Type: Artigo de periódico
Title: Antiproliferative activity and constituents of leaf extracts of Croton sphaerogynus Baill. (Euphorbiaceae)
Author: Motta, LB
Furlan, CM
Santos, DYAC
Salatino, MLF
Negri, G
de Carvalho, JE
Monteiro, PA
Ruiz, ALTG
Caruzo, MB
Salatino, A
Abstract: Several Croton species have been used in traditional medicine and contain substances active against cancer, such as diterpenoids and alkaloids. Croton sphaerogynus is a shrub from the Atlantic Rain Forest in southeastern Brazil. The main goal of this study was to characterize the main constituents of the leaf extracts of C. sphaerogynus and evaluate their in vitro antiproliferative activity against tumor cell lines. Hexane, dichloromethane and methanol extracts of leaves were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on the cell lines 786-0 (kidney), HT-29 (colon), 1(562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). Relevant constituents in dichloromethane and hexane extracts were abietane, podocarpane and clerodane type furano diterpenes. Dicloromethane and hexane extracts exhibited activity against NCI-H460 (GI(50) 0.26 mu g/mL and 0.33 mu g/mL, respectively) and K562 (GI(50) 0.60 mu g/mL and <0.25 mu g/mL, respectively). Taking into account all cell lines tested, the dichloromethane extract was shown to have higher activity (mean log GI(50) 0.86) than hexane and methanol extracts (mean log GI(50) 1.26 and 1.49, respectively). The antiproliferative activity observed in the present work is probably accounted for by the abietane and/or podocarpane diterpenes. (C) 2013 Elsevier B.V. All rights reserved.
Subject: Croton sphaerogynus
Euphorbiaceae
Antiproliferative activity
Diterpenes
Podocarpanes
Abietanes
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.indcrop.2013.08.008
Date Issue: 2013
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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