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Type: Artigo de periódico
Title: Tissue-specific regulation of IRS-2/PI 3-kinase association in aged rats
Author: Carvalho, CRO
Maeda, L
Brenelli, SL
Saad, MJA
Abstract: We have examined the insulin-stimulated IRS-2 association with PI 3-kinase and the phosphorylation of AKT/PKB, which is functionally located downstream of the PI 3-kinase, in aged (obese) rats. The IRS-2 protein levels were similar in 2 and 20 month-old rats in both tissues, liver and muscle. There were reductions in insulin-induced IRS-2 tyrosine phosphorylation in liver and muscle, accompanied by a decrease in IRS-2/PI 3-kinase association and in AKT/PKB phosphorylation only in muscle tissue of aged rats. This regulation may be important in the altered glucose metabolism observed in aged (obese) rats.
Subject: aging
insulin action
insulin receptor substrate-2
insulin resistance
tyrosine phosphorylation
Country: Alemanha
Editor: Walter De Gruyter & Co
Citation: Biological Chemistry. Walter De Gruyter & Co, v. 381, n. 1, n. 75, n. 78, 2000.
Rights: embargo
Identifier DOI: 10.1515/BC.2000.010
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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