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Type: Artigo de periódico
Title: Antioxidant therapy to prevent preeclampsia - A Randomized controlled trial
Author: Spinnato, JA
Freire, S
Silva, JLPE
Rudge, MVC
Martins-Costa, S
Koch, MA
Goco, N
Santos, CD
Cecatti, JG
Costa, R
Ramos, JG
Moss, N
Sibai, BM
Abstract: OBJECTIVE: To study whether antioxidant supplementation will reduce the incidence of preeclampsia among patients at increased risk. METHODS: A randomized, placebo-controlled, double-blind clinical trial was conducted at four Brazilian sites. Women between 12 0/7 weeks and 19 6/7 weeks of gestation and diagnosed to have chronic hypertension or a prior history of preeclampsia were randomly assigned to daily treatment with both vitamin C (1,000 mg) and vitamin E (400 International Units) or placebo. Analyses were adjusted for clinical site and risk group (prior preeclampsia, chronic hypertension, or both). A sample size of 734 would provide 80% power to detect a 40% reduction in the risk of preeclampsia, assuming a placebo group rate of 21% and alpha=.05. The a level for the final analysis, adjusted for interim looks, was 0.0458. RESULTS: Outcome data for 707 of 739 randomly assigned patients revealed no significant reduction in the rate of preeclampsia (study drug, 13.8% [49 of 355] compared with placebo, 15.6% [55 of 352], adjusted risk ratio 0.87 [95.42% confidence interval 0.61-1.25]). There were no differences in mean gestational age at delivery or rates of perinatal mortality, abruptio placentae, pre-term delivery, and small for gestational age or low birth weight infants. Among patients without chronic hypertension, there was a slightly higher rate of severe preeclampsia in the study group (study drug, 6.5% [11 of 170] compared with placebo, 2.4% [4 of 168], exact P=.11, odds ratio 2.78, 95% confidence interval 0.79-12.62). CONCLUSION: This trial failed to demonstrate a benefit of antioxidant supplementation in reducing the rate of preeclampsia among'patients with chronic hypertension and/or prior preeclampsia.
Country: EUA
Editor: Lippincott Williams & Wilkins
Citation: Obstetrics And Gynecology. Lippincott Williams & Wilkins, v. 110, n. 6, n. 1311, n. 1318, 2007.
Rights: fechado
Identifier DOI: 10.1097/01.AOG.0000289576.43441.1f
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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