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Type: Artigo de periódico
Title: Antioxidant SOD Mimetic Prevents NADPH Oxidase-Induced Oxidative Stress and Renal Damage in the Early Stage of Experimental Diabetes and Hypertension
Author: Peixoto, EBMI
Pessoa, BS
Biswas, SK
de Faria, JBL
Abstract: Aims: The presence of hypertension increases renal oxidative stress by increasing NADPH oxidase-dependent superoxide production and by decreasing antioxidant defense in the early stage of experimental diabetes mellitus (DM). In the present study, we investigated whether the administration of an antioxidant mimetic of the superoxide dismutase (SOD) (tempol) corrects the oxidative imbalance and oxidative stress-induced renal injury in the presence of DM and hypertension. Methods: DM was induced in spontaneously hypertensive rats (SHR) by streptozotocin at 4 weeks of age. The diabetic rats either did or did not receive tempol for 20 days. Oxidative-stress parameters and indices of renal injury were evaluated. Results: Tempol reestablished the imbalance in redox status induced by DM. It elevated the expression of renal antioxidant extracellular SOD, p < 0.0001; decreased (p = 0.049) the production of renal NADPH-dependent superoxide production, and diminished (p = 0.016) a marker of oxidative stress-induced DNA damage, 8-hydroxy-2'-deoxyguanosine. Reduction of oxidative stress markers was associated with reduction in renal damage parameters associated with DN. DM-induced albuminuria and elevation in renal expression of collagen IV were reduced to the level ob served in control rats. Conclusion: We conclude that an imbalance in renal redox status is associated with markers of renal injury in the early stage of DM and hypertension. Antioxidant treatment reestablished the redox status and prevented oxidative stress-induced renal damage. Copyright (C) 2008 S. Karger AG, Basel
Subject: Albuminuria
Diabetic nephropathy
Extracellular matrix
Oxidative stress
Spontaneously hypertensive rats
Country: Suíça
Editor: Karger
Citation: American Journal Of Nephrology. Karger, v. 29, n. 4, n. 309, n. 318, 2009.
Rights: fechado
Identifier DOI: 10.1159/000163767
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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