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Type: Artigo de periódico
Title: Antiophidic Solanidane Steroidal Alkaloids from Solanum campaniforme
Author: Torres, MCM
Pinto, FDL
Braz, R
Silveira, ER
Pessoa, ODL
Jorge, RJB
Ximenes, RM
Monteiro, HSA
Evangelista, JSAM
Diz, EBS
Toyama, MH
Abstract: Three new solanidane alkaloids bearing a 22,23-epoxy ring (1-3) and four known compounds were isolated from leaves of Solanum campaniforme. The structures were determined using spectroscopic techniques, including ID and 2D NMR, and HRESIMS experiments. The antiophidic activity of the alkaloids was tested against Bothrops pauloensis venom. Compounds 1-3 completely inhibited myotoxicity without inhibiting phospholipase A(2) activity of the venom, while hemorrhage and skin necrosis were significantly reduced in the presence of alkaloids 1 and 2.
Country: EUA
Editor: Amer Chemical Soc
Citation: Journal Of Natural Products. Amer Chemical Soc, v. 74, n. 10, n. 2168, n. 2173, 2011.
Rights: fechado
Identifier DOI: 10.1021/np200479a
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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