Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/77808
Type: Artigo de periódico
Title: Anti-leishmanial activity of neolignans from Virola species and synthetic analogues
Author: Barata, LES
Santos, LS
Ferri, PH
Phillipson, JD
Paine, A
Croft, SL
Abstract: Surinamensin, a neolignan isolated from Virola surinamensis, 3,4,5-trimethoxy-8-[2',6'-dimethoxy-4'-(E)-prophenylphenoxy]phenylpropane, a neolignan isolated from Virola pavonis, and 25 of its synthetic analogues or correlated substances with ether linkages and their corresponding C-8 sulphur and nitrogen analogues, were tested for activity against Leishmania donovani amastigotes and promastigotes in vitro. Some were active against L. donovani promastigotes at 30 muM but inactive against intracellular amastigotes. The natural neolignan from V. pavonis was active against promastigotes at 100 muM. The highest selective activity was found in those compounds with sulphur bridges. The beta -ketosulfide (3,4-dimethoxy)-8-(4'-methylthiophenoxy) produced 42% inhibition of L. donovani amastigotes in the liver of BALB/c mice at 100 mg/kg given once daily for five consecutive days (P > 0.05). (C) 2000 Elsevier Science Ltd. All rights reserved.
Subject: Virola surinamensis
Virola pavonis
Myristicaceae
Leishmania donovani
beta-ketoethers
beta-ketosulfides
beta-ketoamines
neolignans
anti-leishmanial activity
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/S0031-9422(00)00240-5
Date Issue: 2000
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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