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Type: Artigo de periódico
Title: Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp
Author: Brito, AS
Arimateia, DS
Souza, LR
Lima, MA
Santos, VO
Medeiros, VP
Ferreira, PA
Silva, RA
Ferreira, CV
Justo, GZ
Leite, EL
Andrade, GPV
Oliveira, FW
Nader, HB
Chavante, SF
Abstract: The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug. (C) 2008 Elsevier Ltd. All rights reserved.
Subject: Glycosaminoglycans
Crustacean heparin-like compound
Anti-inflammatory activity
Anticoagulant activity
Hemorrhagic activity
Litopenaeus vannamei
Matrix metalloproteinases
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2008.09.020
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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