Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/77799
Type: Artigo de periódico
Title: Anti-Inflammatory and Antimicrobial Evaluation of Neovestitol and Vestitol Isolated from Brazilian Red Propolis
Author: Bueno-Silva, B
Alencar, SM
Koo, H
Ikegaki, M
Silva, GVJ
Napimoga, MH
Rosalen, PL
Abstract: The objective of this study was to evaluate anti-inflammatory and antimicrobial activities of neovestitol and vestitol isolated from Brazilian red propolis (BRP). BRP ethanolic extract (EEP), neovestitol, and vestitol were evaluated by anti-inflammatory properties using a neutrophil migration assay. The antimicrobial activity was evaluated by minimal inhibitory and bactericidal concentrations (MIC and MBC) against Streptococcus mutans, Streptococcus sobrinus, Staphylococcus aureus, and Actinomyces naeslundii. Neovestitol, vestitol, and EEP inhibited neutrophil migration at a dose of 10 mg/kg. Regarding antimicrobial activity, neovestitol showed MICs ranging from <6.25 to 25-50 mu g/mL and MBCs ranging from 25-50 to 50-100 mu g/mL, while vestitol showed MICs ranging from 25-50 to 50-100 mu g/mL and MBCs ranging from 25-50 to 50-100 mu g/mL. Both isoflavonoids neovestitol and vestitol are consistent bioactive compounds displaying anti-inflammatory and antimicrobial activities that can strongly act in a low dose and concentration and have a promising potential to be applied in the pharmaceutical and food industries.
Subject: anti-inflammatory
antimicrobial
isoflavonoids
neovestitol
vestitol
red propolis
Country: EUA
Editor: Amer Chemical Soc
Rights: fechado
Identifier DOI: 10.1021/jf305468f
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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