Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/77797
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAnti-inflammatory and analgesic potential of hydrolyzed extract of Agave sisalana Perrine ex Engelm., Asparagaceaept_BR
dc.contributor.authorDunder, RJpt_BR
dc.contributor.authorQuaglio, AEVpt_BR
dc.contributor.authorMaciel, RPpt_BR
dc.contributor.authorLuiz-Ferreira, Apt_BR
dc.contributor.authorAlmeida, ACApt_BR
dc.contributor.authorTakayama, Cpt_BR
dc.contributor.authorde Faria, FMpt_BR
dc.contributor.authorSouza-Brito, ARMpt_BR
unicamp.author.emailr065813@dac.unicamp.brpt_BR
unicamp.authorDunder, Ricardo J. Luiz-Ferreira, Anderson Almeida, Ana C. A. Takayama, Christiane de Faria, Felipe M. Souza-Brito, Alba R. M. Univ Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, Lab Prod Nat,Inst Biol, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorQuaglio, Ana E. V. Maciel, Rubens P. Univ Estadual Sao Paulo, Dept Biol, BR-19806900 Assis, SP, Brazilpt_BR
dc.subjectAgave sisalanapt_BR
dc.subjectAsparagaceae Agavoideaept_BR
dc.subjecthemolyticpt_BR
dc.subjectanti-inflammatorypt_BR
dc.subjectanalgesicpt_BR
dc.subject.wosHemolytic Activitiespt_BR
dc.subject.wosSaponinspt_BR
dc.subject.wosInflammationpt_BR
dc.subject.wosDrugspt_BR
dc.subject.wosAdjuvantpt_BR
dc.subject.wosAgentspt_BR
dc.subject.wosEdemapt_BR
dc.subject.wosPawpt_BR
dc.description.abstractThe hemolytic, anti-inflammatory and antinociceptive properties from hydrolyzed extract Agave sisalana Perrine ex Engelm., Asparagaceae (HEAS) was evaluated classic inflammation models. Male Swiss mice and male Wistars rats received HEAS (500 mg/kg) in two administration p.o. and i.p. in saline solution 0.9%. The acid hydrolysis inhibited the hemolytic action of saponins due to the retreat of side chain sugar. The treatment of the ear induced oedema by xylene with HEAS significantly reduced in two routes 13 +/- 1.5 and 10 +/- 0.63 mg, respectively, p.o. and i.p., in comparison with controls 27 1.5 saline and 13.5 +/- 1.2 AAS. The HEAS also diminished edema induced by carrageenin 43 +/- 1.58 mg (p.o.) and 17 +/- 1.26 mg (i.p.), when compared with control groups 52 +/- 1.58 mg (saline) and 10.05 +/- 1.58 (indomethacin). HEAS showed analgesic effects in abdominal constrictions 30.7% (p.o.), 88.7% (i.p.) comparable to that produced by (AAS) 70.6%. However in granuloma cotton pellet a chronic model of inflammation just the i.p. pathway decreased granulomatous tissue (20.4 +/- 1.32 mg) compared with controls 30.5 +/- 2.53 mg (saline) and 20.2 +/- 2.18 mg (dexamethasone). These data suggest that HEAS has anti-inflammatory and analgesic activity on acute and chronic processes.pt
dc.relation.ispartofRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosypt_BR
dc.relation.ispartofabbreviationRev. Bras. Farmacogn.-Braz. J. Pharmacogn.pt_BR
dc.publisher.cityJoao Pessoapt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherSoc Brasileira Farmacognosiapt_BR
dc.date.issued2010pt_BR
dc.date.monthofcirculationJUN-JULpt_BR
dc.identifier.citationRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Soc Brasileira Farmacognosia, v. 20, n. 3, n. 376, n. 381, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume20pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage376pt_BR
dc.description.lastpage381pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0102-695Xpt_BR
dc.identifier.wosidWOS:000280833400013pt_BR
dc.identifier.doi10.1590/S0102-695X2010000300014pt_BR
dc.date.available2014-11-15T17:46:41Z
dc.date.available2015-11-26T16:12:50Z-
dc.date.accessioned2014-11-15T17:46:41Z
dc.date.accessioned2015-11-26T16:12:50Z-
dc.description.provenanceMade available in DSpace on 2014-11-15T17:46:41Z (GMT). No. of bitstreams: 1 WOS000280833400013.pdf: 724945 bytes, checksum: fa1ada89676a85e51a06ccaf7a260851 (MD5) Previous issue date: 2010en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:12:50Z (GMT). No. of bitstreams: 2 WOS000280833400013.pdf: 724945 bytes, checksum: fa1ada89676a85e51a06ccaf7a260851 (MD5) WOS000280833400013.pdf.txt: 27653 bytes, checksum: bfa094605356b52c5cdae7239609476b (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77797pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/77797
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77797-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000280833400013.pdf707.95 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.