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dc.contributor.CRUESPUniversidade Estadual de Campinaspt
dc.typeArtigo de periódicopt
dc.titleAnti-inflammatory and analgesic potential of hydrolyzed extract of Agave sisalana Perrine ex Engelm., Asparagaceaept
dc.contributor.authorDunder, RJpt
dc.contributor.authorQuaglio, AEVpt
dc.contributor.authorMaciel, RPpt
dc.contributor.authorLuiz-Ferreira, Apt
dc.contributor.authorAlmeida, ACApt
dc.contributor.authorTakayama, Cpt
dc.contributor.authorde Faria, FMpt
dc.contributor.authorSouza-Brito, ARMpt
unicamp.author.emailr065813@dac.unicamp.brpt
unicamp.authorDunder, Ricardo J. Luiz-Ferreira, Anderson Almeida, Ana C. A. Takayama, Christiane de Faria, Felipe M. Souza-Brito, Alba R. M. Univ Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, Lab Prod Nat,Inst Biol, BR-13083970 Campinas, SP, Brazilpt
unicamp.authorQuaglio, Ana E. V. Maciel, Rubens P. Univ Estadual Sao Paulo, Dept Biol, BR-19806900 Assis, SP, Brazilpt
dc.subjectAgave sisalanapt
dc.subjectAsparagaceae Agavoideaept
dc.subjecthemolyticpt
dc.subjectanti-inflammatorypt
dc.subjectanalgesicpt
dc.subject.wosHemolytic Activitiespt
dc.subject.wosSaponinspt
dc.subject.wosInflammationpt
dc.subject.wosDrugspt
dc.subject.wosAdjuvantpt
dc.subject.wosAgentspt
dc.subject.wosEdemapt
dc.subject.wosPawpt
dc.description.abstractThe hemolytic, anti-inflammatory and antinociceptive properties from hydrolyzed extract Agave sisalana Perrine ex Engelm., Asparagaceae (HEAS) was evaluated classic inflammation models. Male Swiss mice and male Wistars rats received HEAS (500 mg/kg) in two administration p.o. and i.p. in saline solution 0.9%. The acid hydrolysis inhibited the hemolytic action of saponins due to the retreat of side chain sugar. The treatment of the ear induced oedema by xylene with HEAS significantly reduced in two routes 13 +/- 1.5 and 10 +/- 0.63 mg, respectively, p.o. and i.p., in comparison with controls 27 1.5 saline and 13.5 +/- 1.2 AAS. The HEAS also diminished edema induced by carrageenin 43 +/- 1.58 mg (p.o.) and 17 +/- 1.26 mg (i.p.), when compared with control groups 52 +/- 1.58 mg (saline) and 10.05 +/- 1.58 (indomethacin). HEAS showed analgesic effects in abdominal constrictions 30.7% (p.o.), 88.7% (i.p.) comparable to that produced by (AAS) 70.6%. However in granuloma cotton pellet a chronic model of inflammation just the i.p. pathway decreased granulomatous tissue (20.4 +/- 1.32 mg) compared with controls 30.5 +/- 2.53 mg (saline) and 20.2 +/- 2.18 mg (dexamethasone). These data suggest that HEAS has anti-inflammatory and analgesic activity on acute and chronic processes.pt
dc.relation.ispartofRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosypt_BR
dc.relation.ispartofabbreviationRev. Bras. Farmacogn.-Braz. J. Pharmacogn.pt
dc.publisher.cityJoao Pessoapt
dc.publisher.countryBrasilpt
dc.publisherSoc Brasileira Farmacognosiapt
dc.date.issued2010pt
dc.date.monthofcirculationJUN-JULpt
dc.identifier.citationRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Soc Brasileira Farmacognosia, v. 20, n. 3, n. 376, n. 381, 2010.pt
dc.language.isoenpt
dc.description.volume20pt
dc.description.issuenumber3pt
dc.description.initialpage376pt
dc.description.lastpage381pt
dc.rightsabertopt
dc.sourceWeb of Sciencept
dc.identifier.issn0102-695Xpt
dc.identifier.wosidWOS:000280833400013pt
dc.identifier.doi10.1590/S0102-695X2010000300014pt
dc.date.available2014-11-15T17:46:41Z
dc.date.available2015-11-26T16:12:50Z-
dc.date.accessioned2014-11-15T17:46:41Z
dc.date.accessioned2015-11-26T16:12:50Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:12:50Z (GMT). No. of bitstreams: 2 WOS000280833400013.pdf: 724945 bytes, checksum: fa1ada89676a85e51a06ccaf7a260851 (MD5) WOS000280833400013.pdf.txt: 27653 bytes, checksum: bfa094605356b52c5cdae7239609476b (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77797pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/77797
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77797-
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