Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/77795
Type: Artigo de periódico
Title: Anti-Inflammatory Activity of Chitooligosaccharides in Vivo
Author: Fernandes, JC
Spindola, H
de Sousa, V
Santos-Silva, A
Pintado, ME
Malcata, FX
Carvalho, JE
Abstract: All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatory activity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.
Subject: chitooligosaccharides
anti-inflammatory
animal model
Country: Suíça
Editor: Mdpi Ag
Rights: aberto
Identifier DOI: 10.3390/md8061763
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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