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Type: Artigo de periódico
Title: Total synthesis of 10-deoxymethynolide the aglycon of the macrolide antibiotic 10-deoxymethymycin
Author: Pilli, RA
de Andrade, CKZ
Souto, CRO
de Meijere, A
Abstract: A short and efficient total synthesis of 10-deoxymethynolide (2c), the aglycon of 10-deoxymethymycin (1c), has been accomplished in 16 steps and 12% overall yield from (S)-3-O-p-toluenesulfonyl-3-hydroxy-2-methylpropanal (15c). The synthesis features an expeditious preparation of (+)-5a, a synthetic equivalent of the Prelog-Djerassi lactonic acid, and the construction of a 12-membered lactone through an intramolecular Nozaki-Hiyama-Kishi coupling reaction.
Country: EUA
Editor: Amer Chemical Soc
Rights: fechado
Identifier DOI: 10.1021/jo9809433
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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