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Type: Artigo de periódico
Title: Total synthesis of (-)-basiliskamide B
Author: Dias, LC
Goncalves, CDS
Abstract: The total synthesis of the polyketide antibiotic (-)-basiliskamide B is described. The convergent asymmetric synthesis relies on the use of a diastereoselective ethyl ketone aldol reaction followed by a syn selective reduction of a beta-hydroxy ketone and a Stille cross-coupling between a Z-vinylstannane and an E-vinyl iodide to establish the (Z,E)dienamide moiety.
Subject: aldol reaction
antitumor compounds
Stille cross-coupling
total synthesis
Country: EUA
Editor: Wiley-blackwell
Rights: fechado
Identifier DOI: 10.1002/adsc.200700589
Date Issue: 2008
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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