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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAntihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: Evidence for the inhibition of angiotensin converting enzymept_BR
dc.contributor.authorGasparotto, Apt_BR
dc.contributor.authorGasparotto, FMpt_BR
dc.contributor.authorLourenco, ELBpt_BR
dc.contributor.authorCrestani, Spt_BR
dc.contributor.authorStefanello, MEApt_BR
dc.contributor.authorSalvador, MJpt_BR
dc.contributor.authorda Silva-Santos, JEpt_BR
dc.contributor.authorMarques, MCApt_BR
dc.contributor.authorKassuya, CALpt_BR
unicamp.authorGasparotto Junior, Arquimedes Gasparotto, Francielly Mourao Botelho Lourenco, Emerson Luiz Univ Paranaense, Dept Pharmacol, BR-87502210 Umuarama, PR, Brazilpt_BR
unicamp.authorGasparotto Junior, Arquimedes Botelho Lourenco, Emerson Luiz Crestani, Sandra Andrade Marques, Maria Consuelo Leite Kassuya, Candida Aparecida Univ Fed Parana, Dept Pharmacol, BR-80060000 Curitiba, Parana, Brazilpt_BR
unicamp.authorAlves Stefanello, Maria Elida Univ Fed Parana, Dept Chem, BR-80060000 Curitiba, Parana, Brazilpt_BR
unicamp.authorSalvador, Marcos Jose Univ Estadual Campinas, Inst Biol, Campinas, SP, Brazilpt_BR
unicamp.authorda Silva-Santos, Jose Eduardo Univ Fed Santa Catarina, Dept Pharmacol, Florianopolis, SC, Brazilpt_BR
unicamp.authorLeite Kassuya, Candida Aparecida Fundacao Univ Fed Grande Dourados, Fac Med Sci, Dourados, MS, Brazilpt_BR
dc.subjectTropaeolum majuspt_BR
dc.subjectACE inhibitorspt_BR
dc.subject.wosSpontaneously Hypertensive-ratspt_BR
dc.subject.wosIonization Mass-spectrometrypt_BR
dc.subject.wosAntioxidant Activitypt_BR
dc.subject.wosDeficient Micept_BR
dc.description.abstractAim of the study: Previous studies have shown that the extracts obtained from Tropaeolum majus L exhibit pronounced diuretic properties. In the present study, we assessed whether the hypotensive and/or antihypertensive mechanism of hydroethanolic extract (HETM), semi-purified fraction (TMLR) obtained from T. majus and the flavonoids isoquercitrin (ISQ) and kaempferol (KPF) can be mediated by their interaction with angiotensin converting enzyme (ACE). Methods and methods: Firstly, to evaluate changes in mean arterial pressure (MAP), different groups of normotensive and spontaneously hypertensive rats (SHR) were orally and intraduodenally treated with HETM (10-300 mg/kg) and TMLR (12.5-100 mg/kg) and intravenously treated with ISQ and KPF being later anesthetized with ketamine (100 mg/kg) and xylazine (20 mg/kg). The left femoral vein and the right carotid artery were isolated, and polyethylene catheters were inserted for ISQ and KPF (0.5-4 mg/kg) administration and blood pressure recording, respectively. The plasmatic ACE activity was evaluated to indirect fluorimetry, in serum samples after orally treatment with HETM, TMLR, ISQ and KPF. Results: The oral administration of the HETM and its TMLR significantly reduced, in a dose-dependent manner, the MAP in both normotensive and SHR. In addition, these preparations significantly decreased the MAP for up to 3 h after the administration of the extract. Additionally, the intravenous administration of ISQ but not KPF, decreased MAP in rats. Otherwise, neither the extracts nor ISQ affected the heart rate. The oral administration of the HETM, TMLR or ISQ reduced ACE activity in serum samples at 90 min after administration. Finally, the intravenous administration of ISQ caused a significant reduction in the hypertensive response to angiotensin I, but not angiotensin II in normotensive rats. Conclusion: Our results show that the hypotensive effects caused by the HETM, as well as by its TMLR, may be associated with the high levels of the flavonoid ISQ found in this plant. In addition, ISQ-induced hypotension in rats is an event dependent on the inhibition of angiotensin II generation by ACE. (C) 2010 Elsevier Ireland Ltd. All rights
dc.relation.ispartofJournal Of Ethnopharmacologypt_BR
dc.relation.ispartofabbreviationJ. Ethnopharmacol.pt_BR
dc.publisherElsevier Ireland Ltdpt_BR
dc.identifier.citationJournal Of Ethnopharmacology. Elsevier Ireland Ltd, v. 134, n. 2, n. 363, n. 372, 2011.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
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