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Type: Artigo de periódico
Title: Antifungal activity of goniothalamin enantiomers
Author: Martins, CVB
de Resende, MA
Magalhaes, TFF
Lima, BHS
Watanabe, GA
Ruiz, ALTG
de Carvalho, JE
Pilli, RA
de Fatima, A
Abstract: A large number of human diseases are caused by fungus and the plant kingdom has proven to be a source of antifungal compounds. This work describes the in vitro activity of the natural product (R)-goniothalamin and its synthetic enantiomer, (S)-goniothalamin, against eleven strains of human pathogenic fungi. The minimum inhibitory concentration (MIC) values for both enantiomers were lower than 100 mu g/mL for nine of the fungus strains studied. MIC values for both enantiomers against isolates of the dimorphic fungus Paracoccidioides braziliensis were in the range of 7-22 mu g/mL. (R)- and (S)-goniothalamin were selective for the fungi strains presenting minimal toxic effects on mammalian kidney (Vero) and lung (V79) cell lines.
Subject: fungi infections
antifungal agents
minimum inhibitory concentration
antiproliferative activity
Country: Emirados Árabes Unidos
Editor: Bentham Science Publ Ltd
Citation: Letters In Drug Design & Discovery. Bentham Science Publ Ltd, v. 5, n. 1, n. 74, n. 78, 2008.
Rights: fechado
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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