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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAnti mycobacterial activity of 4 '-bromo-[1,1 '-biphenyl]-4-yl 4-x-phenylmethanone derivatives, and their acute toxicity and cytotoxicitypt_BR
dc.contributor.authorDe Souza, AOpt_BR
dc.contributor.authorJunior, RRSpt_BR
dc.contributor.authorMelo, PSpt_BR
dc.contributor.authorAlderete, JBpt_BR
dc.contributor.authorDe Conti, Rpt_BR
dc.contributor.authorHaun, Mpt_BR
dc.contributor.authorSato, DNpt_BR
dc.contributor.authorDuran, Npt_BR
unicamp.author.emailduran@iqm.unicamp.brpt_BR
unicamp.authorUniv Estadual Campinas, Biol Chem Lab, Inst Quim, BR-13083970 Campinas, SP, Brazil Inst Adolfo Lutz Registro, Ribeirao Preto, Brazil Univ Estadual Campinas, Inst Biol, Brasilia, DF, Brazil Univ Concepcion, Dept Quim Organ, Concepcion, Chile Univ Mogi das Cruzes, Mogi Das Cruzes, Brazilpt_BR
dc.subject.wosTuberculosispt_BR
dc.subject.wosAssaypt_BR
dc.subject.wosSystempt_BR
dc.subject.wosAviumpt_BR
dc.description.abstractThe antimycobacterial activity of nine biphenyl methanone (BPM) derivatives against standard strains of Mycobacterium kansasii, M. avium and M. malmoense was determined by colorimetric assay in microplates with the dye Alamar Blue. Acute toxicity of these compounds was also analyzed by determination of CO(2) concentration in a respirometric assay using Escherichia coli. The compounds showed weak antimycobacterial activity with a minimal inhibitory concentration (MIC) over 0.038 mmol l(-1) and no toxicity was found in E. coli up to 400 mmol l(-1). No cytotoxicity was observed on V79 cells up to 0.35 mmol l(-1) with 7 of the BPM derivatives, with two exceptions (X = SO(2)CH(3), NO(2)) that showed some toxicity. The greatest antimycobacterial activity was observed with the SO(2)CH(3) derivative and the application of Principal Component Analysis (PCA) showed a relationship between structure and antimycobacterial activity of the compounds. Two descriptors, nucleophilic superdelocalizability of carbon atom and pi -hydrophobic constant, were necessary to describe this relationship.pt
dc.relation.ispartofPharmaziept_BR
dc.relation.ispartofabbreviationPharmaziept_BR
dc.publisher.cityEschbornpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisherGovi-verlag Pharmazeutischer Verlag Gmbhpt_BR
dc.date.issued2001pt_BR
dc.date.monthofcirculationNOVpt_BR
dc.identifier.citationPharmazie. Govi-verlag Pharmazeutischer Verlag Gmbh, v. 56, n. 11, n. 871, n. 874, 2001.pt_BR
dc.language.isoenpt_BR
dc.description.volume56pt_BR
dc.description.issuenumber11pt_BR
dc.description.firstpage871pt_BR
dc.description.lastpage874pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0031-7144pt_BR
dc.identifier.wosidWOS:000172288300009pt_BR
dc.date.available2014-08-01T18:21:21Z
dc.date.available2015-11-26T18:04:07Z-
dc.date.accessioned2014-08-01T18:21:21Z
dc.date.accessioned2015-11-26T18:04:07Z-
dc.description.provenanceMade available in DSpace on 2014-08-01T18:21:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2001en
dc.description.provenanceMade available in DSpace on 2015-11-26T18:04:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2001en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77645
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77645-
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