Please use this identifier to cite or link to this item:
|Type:||Artigo de periódico|
|Title:||Anti mycobacterial activity of 4 '-bromo-[1,1 '-biphenyl]-4-yl 4-x-phenylmethanone derivatives, and their acute toxicity and cytotoxicity|
|Author:||De Souza, AO|
De Conti, R
|Abstract:||The antimycobacterial activity of nine biphenyl methanone (BPM) derivatives against standard strains of Mycobacterium kansasii, M. avium and M. malmoense was determined by colorimetric assay in microplates with the dye Alamar Blue. Acute toxicity of these compounds was also analyzed by determination of CO(2) concentration in a respirometric assay using Escherichia coli. The compounds showed weak antimycobacterial activity with a minimal inhibitory concentration (MIC) over 0.038 mmol l(-1) and no toxicity was found in E. coli up to 400 mmol l(-1). No cytotoxicity was observed on V79 cells up to 0.35 mmol l(-1) with 7 of the BPM derivatives, with two exceptions (X = SO(2)CH(3), NO(2)) that showed some toxicity. The greatest antimycobacterial activity was observed with the SO(2)CH(3) derivative and the application of Principal Component Analysis (PCA) showed a relationship between structure and antimycobacterial activity of the compounds. Two descriptors, nucleophilic superdelocalizability of carbon atom and pi -hydrophobic constant, were necessary to describe this relationship.|
|Editor:||Govi-verlag Pharmazeutischer Verlag Gmbh|
|Citation:||Pharmazie. Govi-verlag Pharmazeutischer Verlag Gmbh, v. 56, n. 11, n. 871, n. 874, 2001.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.