Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/776
Type: Artigo de periódico
Title: Transdentinal protective role of sodium ascorbate against the cytopathic effects of H(2)O(2) released from bleaching agents
Author: LIMA, Adriano Fonseca
LESSA, Fernanda Campos Rosetti
MANCINI, Maria Nadir Gasparoto
HEBLING, Josimeri
COSTA, Carlos Alberto de Souza
MARCHI, Giselle Maria
Abstract: Objectives. The objectives of this study were to evaluate the transdentinal cytotoxicity of 10% and 16% carbamide peroxide gel (CP), as well as the ability of the antioxidant, 10% sodium ascorbate (SA), to protect the odontoblasts in culture. Study design. Human dentin discs of 0.5-mm thickness were obtained and were placed into artificial pulp chambers. MDPC-23 odontoblastlike cells were seeded on pulp surface of the discs and the following groups were established: G1-No Treatment (control), G2-10% SA/6hs, G3-10%/CP6hs, G4-10%SA/6hs+10%CP/6hs, G5-16%CP/6hs, and G6-10%SA/6hs+16%CP/6hs. The cell viability was measured by the MTT assay. Results. In groups where 16% CP was used, decreased cell viability was observed. Conversely, the application of 10% SA on the dentin discs, before the use of the CP, reduced the cytotoxic effects of these products on cells. Conclusions. The 16% CP cause a significant decrease in MDPC-23 cell viability and 10% SA was able to partially prevent the toxic effects of CP. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: e70-e76)
Country: Estados Unidos
Editor: MOSBY-ELSEVIER
Citation: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, v.109, n.4, p.E70-E76, 2010
Rights: fechado
Identifier DOI: 10.1016/j.tripleo.2009.12.020
Address: http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000275746200035&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
http://dx.doi.org/10.1016/j.tripleo.2009.12.020
Date Issue: 2010
Appears in Collections:FOP - Artigos e Materiais de Revistas Científicas

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