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Type: Artigo de periódico
Title: ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells
Author: Traina, F
Favaro, PMB
Medina, SD
Duarte, ADS
Winnischofer, SMB
Costa, FF
Saad, STO
Abstract: In the present study, increased levels of ANKHD1 mRNA and protein expression in leukemia cell lines are reported, as compared with normal hematopoietic cells. Furthermore, a higher expression of ANKHD1 mRNA was detected in primary acute leukemia samples than in normal hematopoietic cells (P=0.002). ANKHD1 was detected in the cytosolic and membrane fraction of cells and was co-immumoprecipitated with SHP2 in protein extracts of K562 and LNCaP cell lines. These findings suggest a role for ANKHD1 as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. (c) 2006 Elsevier B.V. All rights reserved.
Subject: ANKHD1
ankyrin repeat
SHP2 phosphatase
acute leukemia
Country: Holanda
Editor: Elsevier Science Bv
Citation: Biochimica Et Biophysica Acta-molecular Basis Of Disease. Elsevier Science Bv, v. 1762, n. 9, n. 828, n. 834, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.bbadis.2006.07.010
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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