Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/77572
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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cellspt_BR
dc.contributor.authorMachado-Neto, JApt_BR
dc.contributor.authorLazarini, Mpt_BR
dc.contributor.authorFavaro, Ppt_BR
dc.contributor.authorFranchi, GCpt_BR
dc.contributor.authorNowill, AEpt_BR
dc.contributor.authorSaad, STOpt_BR
dc.contributor.authorTraina, Fpt_BR
unicamp.author.emailftraina@fmrp.usp.brpt_BR
unicamp.authorMachado-Neto, Joao Agostinho Lazarini, Mariana Favaro, Patricia Olalla Saad, Sara Teresinha Traina, Fabiola Univ Estadual Campinas, Hematol & Hemotherapy Ctr, Hemoctr, Inst Nacl Ciencia & Tecnol Sangue,UNICAMP, BR-13083878 Campinas, SP, Brazilpt_BR
unicamp.authorFavaro, Patricia Univ Fed Sao Paulo, Dept Biol Sci, Sao Paulo, Brazilpt_BR
unicamp.authorFranchi, Gilberto Carlos, Jr. Nowill, Alexandre Eduardo Univ Estadual Campinas, Integrated Ctr Childhood Oncohematol Invest, BR-13083878 Campinas, SP, Brazilpt_BR
unicamp.authorTraina, Fabiola Univ Sao Paulo, Dept Internal Med, Ribeirao Preto Med Sch, Sao Paulo, Brazilpt_BR
dc.subjectANKHD1pt_BR
dc.subjectYAP1pt_BR
dc.subjectMASKpt_BR
dc.subjectHippo pathwaypt_BR
dc.subjectProstate cancerpt_BR
dc.subjectCell cyclept_BR
dc.subject.wosTead/tef Familypt_BR
dc.subject.wosAnkyrin Repeatpt_BR
dc.subject.wosSize-controlpt_BR
dc.subject.wosProliferationpt_BR
dc.subject.wosTranscriptionpt_BR
dc.subject.wosProteinpt_BR
dc.subject.wosGrowthpt_BR
dc.subject.wosMaskpt_BR
dc.subject.wosGenespt_BR
dc.subject.wosWwpt_BR
dc.description.abstractANKHD1 is a multiple ankyrin repeat containing protein, recently identified as a novel member of the Hippo signaling pathway. The present study aimed to investigate the role of ANKHDI in DU145 and LNCaP prostate cancer cells. ANKHD1 and YAP1 were found to be highly expressed in prostate cancer cells, and ANKHD1 silencing decreased cell growth, delayed cell cycle progression at the S phase, and reduced tumor xenograft growth. Moreover, ANKHD1 knockdown down-regulated YAP1 expression and activation, and reduced the expression of CCNA2, a YAP1 target gene. These findings indicate that ANKHD1 is a positive regulator of YAP1 and promotes cell growth and cell cycle progression through Cyclin A upregulation. (C) 2014 Elsevier Inc. All rights reserved.pt
dc.relation.ispartofExperimental Cell Researchpt_BR
dc.relation.ispartofabbreviationExp. Cell Res.pt_BR
dc.publisher.citySan Diegopt_BR
dc.publisher.countryEUApt_BR
dc.publisherElsevier Incpt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculation40330pt_BR
dc.identifier.citationExperimental Cell Research. Elsevier Inc, v. 324, n. 2, n. 137, n. 145, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume324pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage137pt_BR
dc.description.lastpage145pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0014-4827pt_BR
dc.identifier.eissn1090-2422pt_BR
dc.identifier.wosidWOS:000336826400003pt_BR
dc.identifier.doi10.1016/j.yexcr.2014.04.004pt_BR
dc.date.available2014-08-01T18:20:54Z
dc.date.available2015-11-26T17:06:26Z-
dc.date.accessioned2014-08-01T18:20:54Z
dc.date.accessioned2015-11-26T17:06:26Z-
dc.description.provenanceMade available in DSpace on 2014-08-01T18:20:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:06:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77572
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77572-
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