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Type: Artigo de periódico
Title: ANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cells
Author: Machado-Neto, JA
Lazarini, M
Favaro, P
Franchi, GC
Nowill, AE
Saad, STO
Traina, F
Abstract: ANKHD1 is a multiple ankyrin repeat containing protein, recently identified as a novel member of the Hippo signaling pathway. The present study aimed to investigate the role of ANKHDI in DU145 and LNCaP prostate cancer cells. ANKHD1 and YAP1 were found to be highly expressed in prostate cancer cells, and ANKHD1 silencing decreased cell growth, delayed cell cycle progression at the S phase, and reduced tumor xenograft growth. Moreover, ANKHD1 knockdown down-regulated YAP1 expression and activation, and reduced the expression of CCNA2, a YAP1 target gene. These findings indicate that ANKHD1 is a positive regulator of YAP1 and promotes cell growth and cell cycle progression through Cyclin A upregulation. (C) 2014 Elsevier Inc. All rights reserved.
Subject: ANKHD1
Hippo pathway
Prostate cancer
Cell cycle
Country: EUA
Editor: Elsevier Inc
Citation: Experimental Cell Research. Elsevier Inc, v. 324, n. 2, n. 137, n. 145, 2014.
Rights: fechado
Identifier DOI: 10.1016/j.yexcr.2014.04.004
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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