Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Transdermal nicotine mimics the smoking-induced endothelial dysfunction
Author: Sabha, M
Tanus-Santos, JE
Toledo, JCY
Cittadino, M
Rocha, JC
Moreno, H
Abstract: Background: Cigarette smoking is a major risk factor for coronary artery disease and causes endothelial dysfunction, perhaps by decreasing the availability of nitric oxide availability in arteries and veins. Nicotine in cigarette smoke may be responsible for this impaired endothelial response. Methods: We studied nine healthy nonsmokers and 12 healthy mild to moderate smokers by use of the dorsal hand vein compliance technique. Dose-response curves to bradykinin and sodium nitroprusside were obtained to test the endothelium-dependent and endothelium-independent vasorelaxation before and during the use of a nicotine (21 mg) patch. Mean arterial blood pressure and heart rate were measured beat-to-beat during the 4-hour study and serial blood samples were drawn to assay plasma thromboxane B-2 levels. Results: Transdermal nicotine reduced the venous responsiveness to bradykinin in nonsmokers (E-max = 88.0% +/- 17.9% and 54.3% +/- 14.9%, respectively, before and after the nicotine patch; P <.05); the latter response was similar to that in smokers (E-max = 56.3% +/- 16.6%). Sodium nitroprusside-induced venodilation was unaltered. Mean arterial blood pressure increased in both smokers and nonsmokers. Transdermal nicotine increased the plasma thromboxane B-2 concentrations only among nonsmokers, Conclusion: These findings indicate that nicotine can have a major role in the impaired endothelial function in smokers. The results probably also reflect what occurs in arterial beds because the nicotine patches increased the mean arterial blood pressure in both smokers and nonsmokers.
Country: EUA
Editor: Mosby, Inc
Citation: Clinical Pharmacology & Therapeutics. Mosby, Inc, v. 68, n. 2, n. 167, n. 174, 2000.
Rights: fechado
Identifier DOI: 10.1067/mcp.2000.108851
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000088938500009.pdf65.46 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.