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Type: Artigo de periódico
Title: Angiotensin-converting enzyme and apolipoprotein B polymorphisms in coronary artery disease
Author: Mansur, AD
Annicchino-Bizzacchi, J
Favarato, D
Avakian, SD
Cesar, LAM
Ramires, JAF
Abstract: The association between angiotensin-converting enzyme (ACE) as well as apolipoprotein B polymorphisms and dyslipidemia and coronary artery disease (CAD) is controversial. We assessed the distribution of ACE insertion and/or deletion, apolipoprotein B signal peptide insertion and/or deletion, and apolipoprotein B Xbal restriction fragment length polymorphisms in 388 nondiabetic patients. We studied 112 patients with angiographically defined asymptomatic CAD or with stable functional classes I and II angina and 139 patients with acute myocardial infarction who were age matched to 137 control subjects. Univariate analysis showed higher prevalence of Xbal X+/X+ genotype in patients with CAD (p = 0.02), ACE and apolipoprotein polymorphisms were not associated with lipid levels and the number of major coronary artery vessels with >50% reduction of lumen diameter. Overall, multivariable regression disclosed traditional risk factors and elevated levels of apolipoprotein B for men and reduced levels of apolipoprotein Al for women as independent variables for CAD. After adjustment for the most important subset of risk factors (age, hypertension, hypercholesterolemia, and smoking), apolipoprotein B Xbal polymorphism was disclosed as an independent variable for CAD. Apolipoprotein B Xbal was also selected as an independent variable for acute myocardial infarction after adjusting for age, hypertension, hypercholesterolemia, and smoking. Thus, in addition to traditional coronary risk factors, apolipoproteins B and Al, and apolipoprotein B Xbal polymorphism could be considered predictors of CAD. (C) 2000 by Excerpta Medica, Inc.
Country: EUA
Editor: Excerpta Medica Inc
Citation: American Journal Of Cardiology. Excerpta Medica Inc, v. 85, n. 9, n. 1089, n. 1093, 2000.
Rights: fechado
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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