Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/77433
Type: Artigo de periódico
Title: TOXICITY AND ANTIOXIDANT ACTIVITY OF FLAVONOIDS FROM Lonchocarpus filipes ROOT BARK.
Author: Santos, EL
Costa, EV
Marques, FA
Vaz, NP
Maia, BHLNS
Magalhaes, EG
Tozzi, AMA
Abstract: TOXICITY AND ANTIOXIDANT ACTIVITY OF FLAVONOIDS FROM Lonchocarpus filipes ROOT BARK. The phytochemical investigation of dichloromethane extract from root bark of Lonchocarpus filipes Benth (Leguminosae) afforded four flavonoids including three dibenzoylmethane derivatives rarely found in nature. The structures were established based on their spectral data ((1)H and (13)C NMR, 2D-NMR) as being: lanceolatin B (1), pongamol (2), (E)-7-O-methylpongamol (3) and (E)-9-O-methylpongamol (4). Compound (4) is described herein for the first time as a natural product. The extracts and the isolated compounds (1), (2) and (3) displayed high toxicity in the brine shrimp lethality assay. Only compound (2) showed antioxidant activity using a DPPH radical scavenging assay. This is the first report on the phytochemical study of Lonchocarpus filipes.
Subject: Lonchocarpus filipes
flavonoids
dibenzoylmethanes
Country: Brasil
Editor: Soc Brasileira Quimica
Rights: aberto
Date Issue: 2009
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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