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|Type:||Artigo de periódico|
|Title:||TOXICITY AND ANTIOXIDANT ACTIVITY OF FLAVONOIDS FROM Lonchocarpus filipes ROOT BARK.|
|Abstract:||TOXICITY AND ANTIOXIDANT ACTIVITY OF FLAVONOIDS FROM Lonchocarpus filipes ROOT BARK. The phytochemical investigation of dichloromethane extract from root bark of Lonchocarpus filipes Benth (Leguminosae) afforded four flavonoids including three dibenzoylmethane derivatives rarely found in nature. The structures were established based on their spectral data ((1)H and (13)C NMR, 2D-NMR) as being: lanceolatin B (1), pongamol (2), (E)-7-O-methylpongamol (3) and (E)-9-O-methylpongamol (4). Compound (4) is described herein for the first time as a natural product. The extracts and the isolated compounds (1), (2) and (3) displayed high toxicity in the brine shrimp lethality assay. Only compound (2) showed antioxidant activity using a DPPH radical scavenging assay. This is the first report on the phytochemical study of Lonchocarpus filipes.|
|Editor:||Soc Brasileira Quimica|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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