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Type: Artigo de periódico
Title: Angiogenesis in salivary carcinomas with and without myoepithelial differentiation
Author: Costa, AF
Demasi, APD
Bonfitto, VLL
Bonfitto, JFL
Furuse, C
Araujo, VC
Metze, K
Altemani, A
Abstract: To investigate whether salivary carcinomas with and without myoepithelial differentiation could present differences regarding degree of angiogenesis, we compared tumor vascularization between adenoid cystic (31 cases) and epithelial-myoepithelial carcinomas (14) versus mucoepidermoid (37) carcinoma. The expression of peroxiredoxin I was also studied to verify the potential relationship between cellular metabolism and microvascular density. Microvascular density for CD34 and CD105 were significantly lower in carcinomas with myoepithelial differentiation. However, no correlation was found between degree of angiogenesis and amounts of myoepithelial cells. High-grade peroxiredoxin I expression was found in 73.7% of mucoepidermoid carcinomas, whereas 85.1% of carcinomas with myoepithelial differentiation presented low-grade expression. In conclusion, carcinomas with myoepithelial differentiation, regardless of the amounts of myoepithelial cells, are associated to a significantly lower vascular density. The reasons for this lower angiogenic activity remain to be determined but could be related to metabolic characteristics of the cancer cells.
Subject: angiogenesis
adenoid cystic carcinoma
mucoepidermoid carcinoma
epithelial-myoepithelial carcinoma
myoepithelial cell and microvessel density
Country: EUA
Editor: Springer
Citation: Virchows Archiv. Springer, v. 453, n. 4, n. 359, n. 367, 2008.
Rights: fechado
Identifier DOI: 10.1007/s00428-008-0664-z
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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