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Type: Artigo de periódico
Title: Treatment of prolymphocytic leukemia with cladribine
Author: Lorand-Metze, I
Oliveira, GB
Aranha, FJP
Abstract: Prolymphocytic leukemia (PLL) is a rare lymphoproliferative disorder that takes a rapidly progressive course and where therapeutic interventions are often unsuccessful. In this context, the new purine analogs may be a promising option. We report two cases of PLL treated with cladribine. The first patient had been resistant to polychemotherapy (COP) but responded well to two courses of 2-CdA. He achieved a partial remission, which he maintained for 15 months. The second patient had very advanced disease but obtained a partial response after three courses of 2-CdA, given as a first-line therapy in an ambulatory setting. These results, as well others reported in the literature, permit us to consider 2-CdA as a highly promising therapeutic option for PLL.
Subject: prolymphocytic leukemia
Country: EUA
Editor: Springer Verlag
Citation: Annals Of Hematology. Springer Verlag, v. 76, n. 2, n. 85, n. 86, 1998.
Rights: fechado
Identifier DOI: 10.1007/s002770050368
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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