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Type: Artigo de periódico
Title: Treating oral histoplasmosis in an immunocompetent patient
Author: Munante-Cardenas, JL
de Assis, AF
Olate, S
Lyrio, MCN
de Moraes, M
Abstract: Background. Histoplasmosis is a deep fungus infection that occurs worldwide and is caused Histoplasma capsulatum. Oral histoplasmosis has been of considerable importance in recent years because it occurs frequently in immunosuppressed patients, more often in those who test positive for the human immunodeficiency virus (HIV). However the literature contains reports of histoplasmosis in immunocompetent patients, especially in endemic areas. Case Description. The authors describe a case of an HIV-negative, immunocompetent 60-year-old man with ulcerative and painful oral lesions. The clinician included squamous cell carcinoma and systemic mycosis in the differential diagnosis. After the patient underwent a biopsy and a definitive diagnosis was reached, this initial treatment regimen included itraconazole (200 milligrams per day for one month), nystatin and chlorhexidine mouthrinse (0.12 percent, 10 milliliters, two times a day). The itraconazole treatment was continued for three more months (100 mg daily) until the lesions had resolved completely. Clinical Implications. Clinicians need to conduct a careful clinical evaluation and make an accurate diagnosis of ulcerated oral lesions. Knowledge of the oral manifestations of histoplasmosis may enable clinicians to reach a diagnosis earlier and initiate therapy more quickly.
Subject: Oral pathology
fungal infections
oral ulcers
antifungal agents
Country: EUA
Editor: Amer Dental Assoc
Citation: Journal Of The American Dental Association. Amer Dental Assoc, v. 140, n. 11, n. 1373, n. 1376, 2009.
Rights: fechado
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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