Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/77112
Type: Artigo de periódico
Title: Albendazole sulfoxide enantiomers: Preparative chiral separation and absolute stereochemistry
Author: Lourenco, TC
Batista, JM
Furlan, M
He, YA
Nafie, LA
Santana, CC
Cass, QB
Abstract: The enantiomeric separation of albendazole sulfoxide was carried out by simulated moving bed chromatography with variable zones (VARICOL). An overall recovery of 97% was achieved and enantiomeric ratios of 99.5% for raffinate and 99.0% for extract were attained. A total of 880 mg of (+)-albendazol sulfoxide and 930 mg of its antipode were collected after 55 cycles or 11 h of process, resulting in a mass rate of 2 g/day. Furthermore the absolute configuration of the enantiopure compounds was determined for the first time by vibrational circular dichroism (VCD) with the aid of theoretical calculations as (-)-(S) and (+)-(R)-albendazole sulfoxide. (C) 2012 Elsevier B.V. All rights reserved.
Subject: Albendazole sulfoxide
Simulated moving bed chromatography
VARICOL process
Multimilligram enantiomeric separation
Vibrational circular dichroism
Absolute configuration
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.chroma.2012.01.070
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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